Assays for difficult to screen enzyme targets

Eliminating false positives from enzyme-coupled assays.

Researchers deprioritize good targets all the time—not because the biology is wrong, but because there’s no methods with sufficient throughput and signal-to-noise to enable screening. The fallback is LC-MS. Mass spectrometry is used in drug discovery not because teams want to use it, but because they have no other option.
We build direct biological sensors for metabolites and enzyme products that cannot be measured reliably with conventional assays. Direct and kinetic detection of your molecule of interest: no enzyme-coupled reactions, no secondary readouts.

Targets in development

Isocitrate Lyase

A validated target for TB persistence with no existing HTS-compatible assay. We're building a real-time FRET-based screen.

Serine Racemace

Critical enzyme implicated across several CNS conditions. We're building a high-throughput screen for inhibitor discovery.

Proprietary methods, industry-leading throughput

We’ve developed proprietary methods for building FRET-based assays against drug targets. Our assays directly measure molecule concentration—no coupled enzyme cascades adding noise to your signal. Teams use Percepta to stop troubleshooting the assay and start making chemistry decisions.

How do we construct these assays? We developed state of the art methods to optimize millions of assay variations simultaneously. We leverage deep learning on these datasets to guide future iterations of assay optimization.

Reach out to learn how our proprietary assay platforms can support your research .

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