A sensor that binds your molecule, and nothing in between.
Percepta assays are FRET-based biological sensors: a binding protein engineered so that occupancy by the target molecule changes the distance between two fluorophores. The ratio of the two emission channels reports concentration directly, continuously, and in the well.
Ratiometric, so the well can't fool you.
A single-channel read drifts with sensor concentration, path length, pipetting error and photobleaching. Dividing one emission channel by the other cancels those terms, leaving fractional occupancy of the sensor.
Binding is reversible, so the signal tracks concentration as it changes — a kinetic trace rather than a destructive endpoint. Initial rates, not just plateaus.
Three stages, run as a loop rather than a pipeline.
Diffusion foundation
We run diffusion models on proprietary sequence datasets to generate starting sensor candidates for a given binding problem.
Sensor generation
Given a molecular input representation, the model samples diverse candidate sensors and progressively denoises toward high-probability sequence solutions.
Lab optimisation loop
Candidates are advanced through proprietary high-throughput engineering workflows to iteratively optimise expression, dynamic range, sensitivity and specificity.
Because stage three produces measurements on millions of variants, its output becomes training data for stage one. Each target we build makes the next one faster.
Enter your compound of interest. Watch a sensor converge.
Set the number of diffusion steps and generate. The visualisation shows a simulated diffusion trajectory and converging per-residue confidence over time.
Disclaimer: this demo is illustrative only and does not represent meaningful or functional sensor sequences.
Have a target with no assay?
That's the work we do. Tell us the molecule and the sample type and we'll tell you whether we can build a sensor for it.