Itaconate Assay Kit
Direct, real-time quantification of itaconate in a homogeneous well. No enzyme-coupled reactions, no secondary readouts, no derivatisation.
A metabolite that behaves like a signalling molecule.
Itaconate is an immunometabolite produced by activated macrophages via the enzyme ACOD1 (IRG1). It is not a metabolic side-product: it modulates NF-κB and NLRP3 inflammasome activity and activates Nrf2-dependent antioxidant responses.
That makes the itaconate axis an attractive point of intervention — and accurate measurement the bottleneck. Our assay reports concentration directly and continuously. Just mix your sample and read.
ACOD1 inhibitor screening
Kinetic readout of enzyme activity in plate format, with initial rates rather than endpoints.
Macrophage activation studies
Track itaconate output across stimulation conditions and time courses without destructive sampling.
Immunometabolism profiling
Quantify a defined node of the immunometabolic response alongside your existing panels.
Request information for the Itaconate Assay Kit
Contact us for availability, pricing and early access. Our team is happy to provide technical details and help you select the right configuration for your work.